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題名 | Group B Streptococcus Infection in Infancy: 21-Year Experience=嬰兒期B型鏈球菌感染:二十一年之經驗 |
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作者 | 廖鏘華; 黃立民; 呂俊毅; 李慶雲; 薛博仁; 曹伯年; 謝武勳; 鄒國英; Liao, Chiang-hua; Huang, Li-min; Lu, Chun-yi; Lee, Chin-yun; Hsueh, Po-ren; Taso, Po-nien; Hsieh, Wu-shiun; Tsou, Kuo-inn; |
期刊 | 臺灣兒科醫學會雜誌 |
出版日期 | 20021100、20021200 |
卷期 | 43:6 民91.11-12 |
頁次 | 頁326-329+371 |
分類號 | 417.515 |
語文 | eng |
關鍵詞 | B型鏈球菌感染; 嬰兒; 早期發病; 晚期發病; Group B streptococcus; Infant; Early onset; Late onset; |
中文摘要 | 有關於B型鏈球菌感染的臨床症狀作臨床回顧分析,收集從1980到2000年期間的個案。在25個受到B型鏈球菌感染的嬰兒中,其中9個(36%)嬰兒是早期發病,12個(48%)爲晚期發病,4個(16%)在3個月大以後才發病,在早期發病的嬰兒中有89%在出生後一天內發病,其中有33%爲早産兒。在B型鏈球菌感染的臨床症狀以發燒表現佔75%、活動力差25%、呼吸窘迫25%、嗜睡20%、燥動不安20%。在腦膜炎感染的嬰兒中31%有癲癇表現。早期發病比晚期發病的嬰兒産生較高比例的肺炎(66%)及致死率(33.3%),在晚期發病的嬰兒較多以腦膜炎症狀表現(77%),及有較高的後遺症(40%),在8個分離出的B型鏈球菌菌株對penicillin,ampicillin,cefotaxime,vancomycin具敏感性,在分離出的B型鏈球菌菌株中若具有較高最低限度抑制濃度(MIC),則有較高比例嚴重的神經性後遺症,菌株對erythromycin及clindamycin的敏感必分別爲62%及75%。從血液及腦脊髓液分離出的菌株中大部份爲第三型B型鏈球菌。 |
英文摘要 | In this hospital-based review, clinical presentations associated with Group B streptococcus (GBS) infections in children occurring between January 1980 and March 2000 were analyzed. Among the 25 infants with invasive group B streptococcal infections, 9 (36%) were early onset diseases (EOD), 12 (48%) were late onset diseases (LOD), and 4 (16%) occurred beyond the third month of life. Eight of the nine (89%) EOD cases manifested during the first day of life and three (33%) were premature births. Common presentations in GBS infection were fever (75%), poor activity (25%), respiratory distress (25%), lethargy (20%), and irritability (20%). Seizure occurred in 31% of infants with meningitis. Pneumonia (66%) and case-fatality rate (33.3%) were significantly higher in EOD than in LOD. Meningitis was the major manifestation (77%) of LOD and had severe sequelae in 40% of cases. Eight strains were assayed for antibiotic sensitivity and they were all susceptible to penicillin, ampicillin, cefotaxime, and vancomycin. The susceptibilities to erythromycin and clindamycin were 62% and 75%, respectively. Most of the strains from blood or cerebrospinal fluid were type Ⅲ. |
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