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題名 | 牛乳IgG儲存安定性與免疫活性之研究=Storage Stability and Immunological Activity of Bovine Milk Immunoglobulin G |
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作者 | 陳昭誠; 杜艷櫻; 張鴻民; Chen, Chao-cheng; Tu, Yann-ying; Chang, Hung-min; |
期刊 | 嘉南學報 |
出版日期 | 19991100 |
卷期 | 25 1999.11[民88.11] |
頁次 | 頁21-30 |
分類號 | 473.7 |
語文 | chi |
關鍵詞 | 牛乳IgG; 安定性; 免疫活性; 脂多醣; Bovine milk IgG; Stability; Immunological activity; Lipopolysaccharide; |
中文摘要 | 利用口服方式攝入免疫球蛋白以增強人體之免疫力已為多數學者所報導,研究發 現可抑制腸毒型大腸桿菌(Escherichia coli)與輪狀病毒(rotavirus)的感染,以避免下痢發 生,建議在嬰兒乳粉中添加免疫球蛋白以預防感染病菌。因此探討有關牛乳IgG在加工過程 和儲存期間的安定性變化是很重要的,研究結果顯示冷凍乾燥精製IgG粉末和乳清粉末在較 低的溫度下儲度較安定。牛乳IgG與四種微生物(E.coli O55:B5、Salmonella enteritidis、 E. coli O111:B4和Salmonella typhosa)之脂多醣作用結果顯示,其中E. coli O111:B4 之ELlSA值較高。可見牛乳IgG對人體易感染之細菌仍具有抗原一抗體結合反應,證實牛乳 IgG確實具有免疫活性。 |
英文摘要 | The enhancement or Immunity against diseases by oral administration of antibodies of avoid diarrhea have been reportes to be effective in prevening the infection of enterotoxic Escherichia coli and rotovirus. Suggestions have been made to fortify the immunity of young children by adding the immunoglobulins to the infant formula. Thus, the investigation on the bovine milk IgG stability will be very important. Out result shows that freeze-dried bovine milk IgG and colostral whey powders are stable at lower temperature. The ELISA value against E. coli O111: 114 is the most dominant when colostral IgG is reacted with various lipopolysaccharides isolated from four different bacteria including E. coil O55: 115 Salmonella enterltidis、E. coli O111: B4 and Salmonella typhosa. This result reveals a fact that the antibodies in the native bovine milk could protect the consumers from being infected by such specie of bacteria. |
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