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頁籤選單縮合
題名 | Differentiation between Neonatal Extrahepatic and Intrahepatic Cholestasis=積延性新生兒黃疸之鑑別診斷 |
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作者 | 詹聖霖; 陳昭惠; 林捷忠; 遲景上; Jan, S. L.; Chen, C. H.; Lin, C. C.; Chi, C. S.; |
期刊 | Clinical Neonatology |
出版日期 | 19970100 |
卷期 | 4:1 1997.01[民86.01] |
頁次 | 頁10-15 |
分類號 | 417.509 |
語文 | eng |
關鍵詞 | 新生兒黃疸; Neonatal cholestasis; Abdominal ultrasound; Tc-99m DISIDA cholescintigraphy; Neonatal cholestasis score; |
英文摘要 | Neonatal cholestasis (NC) is a relatively common disease in the first month of life. We carried out a retrospective investigation of 44 infants in whom NC was diagnosed and treated at Taichung Veterans General Hospital between January 1990 and August 1995. NC was categorized as either extrahepatic cholestasis (EXC) or intrahepatic cholestasis (INC) based on radiographic vidence or histopathology of biopsy specimens. The values of 14 analytes, abdominal ultrasound and Tc-99m DISIDA cholescintigraphy were compared between EXC with INC patient groups. The graphical approach to laboratory data analysis was used for selecting more reliable cut-off points as discriminant values and use these values to calculate the neonatal cholestasis score. In our study, the serum level of gamma-glutamyl transpeptidase (γ-GT), direct and total bilirubin, the γ-GT/ alkaline phosphatase (ALP) ratio and the total bilirubin/ γ-GT ratio were all statistically significant (p<0.05) and their remainders were not significantly variant. In addition, the NC score showed that EXC patients had a higher score than INC patients. These results suggest that findings of a high neonatal cholestasis score (≧ 6), absence or small size of the gallbladder on ultrasound at least 6 hours after NPO and non detection of isotope in bowel excretion after 24 hours on cholescintigraphy may aid in the differential diagnosis of EXC and INC in infants. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。