頁籤選單縮合
題 名 | Torsade de Pointes Induced by Metoclopramide in an Elderly Woman with Preexisting Complete Left Bundle Branch Block=Metoclopramide引發之多型態心室頻脈於一位有左束枝完全阻斷之老婦人 |
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作 者 | 周宗川; 吳德朗; | 書刊名 | 長庚醫學 |
卷 期 | 24:12 2001.12[民90.12] |
頁 次 | 頁805-809 |
分類號 | 415.31 |
關鍵詞 | 多型態心室性頻脈; 腸胃蠕動促進劑; 後天QT延長症候群; Torsade de pointes; Metoclopramide; Acquired long QT syndrome; |
語 文 | 英文(English) |
中文摘要 | 有多種藥物可誘發多型態心室頻脈(Torsade de pointes, TdP)。Metocloopramide是一種常用於止吐及促進腸骨進蠕動的藥物,即使它與抗心律不整藥物procainamide化學結構相當類似,過去並未有與TdP有關之病例報告。本文報告是一位92歲的女性,心電圖呈現左束枝完全阻斷,在給予靜脈注射及口服metoclopramide後不久發生TdP,本病患於住院期間,同時給予cisapride及erythromycin亦引起TdP。本文metoclopramide引起臨床之TdP的第一次報告,爾後metoclopramide臨床使用於TdP之高危險病人須要小心。 |
英文摘要 | There is growing list of drugs implicated in acquired long QT syndrome and torsade de pointes. However, the torsadogenic potential of mectoclolpramide, a commonly used antiemetic and prokinetic drug, has not been reported in the literature, despite its chemical similarity to procainamide. We report on a 92-year-old woman with preexisting complete left bundle branch block who developed torsade de pointes after intravenous and oral administration of metoclopramide. This patient also developed torade de pointes when cisapride and erythromycin were given simulataneously. These two episodes were suppressed successfully after discontinuing the offending drugs and administering class IB drugs. This is the first documentation athat metoclopramide provokes torsade de pointes clinically. Metecolopramide should be used cautiously in patients with a risk of torsade de pointes. |
本系統中英文摘要資訊取自各篇刊載內容。