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題名 | Role of Testosterone in Regulating the Hematocrit, Heart Rate, and Blood Pressure in Rats=睪固酮對大鼠血容比、心跳及血壓之影響 |
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作者 | 王瑞瑤; 董明倫; 王唯峰; 董玉凡; 王錫崗; Wang, Ray-yan; Doong, Ming-luen; Wang, Wee-fong; Tung, Yuh-fan; Wang, Paulus S; |
期刊 | 中華民國物理治療學會雜誌 |
出版日期 | 19960100 |
卷期 | 21:1 1996.01[民85.01] |
頁次 | 頁41-45 |
分類號 | 383.18 |
語文 | eng |
關鍵詞 | 睪固酮; 血壓; 血容比; 大鼠; Testosterone; Systolic arterial pressure; Hematocrit; Rats; |
中文摘要 | 本實驗圭在探討睪固嗣對大鼠血容比、心跳速率及血壓調控所扮演之角 色。雄鼠去睪丸成假性去睪丸二星期後開始本實驗,共睪丸之雄鼠每天以皮下注 射初油酸睪固酮(TP,20 mg/kg.BW)或注射芝麻油,連續注射7天後測其血壓、心跳 速率及血容此之變化。利用血壓記錄儀由鼠尾記錄血壓值及心跳速率,另在大鼠 於乙醚麻醉下由心臟採血,取得血樣離心後,測其血容比。結果顯示去睪丸造成 血容比、血壓及心跳速率均明顯下降(P<0.05),而精囊之重量及血漿中睪固酮亦 會因去睪丸手術而明顯下降(P<0.01)。注射初油酸睪固酮之去睪丸雄鼠,其血容 比、心跳速率及血壓均可回復至原來程度,本文並討論睪固酮對血容比及血壓之 調控機轉。(中華物療誌1996;21(1):41-45) |
英文摘要 | The role of testosterone in regulating the hematocrit, blood pressure (BP) and heart rate inrats (n=7 or 8 rats for each group) was studied. Male rats were orchiectomized (Orch) or shamOrch for 2 weeks. The Orch rats were then injected subcutaneously with testosterone propionate(TP, 20 mg/kg BW) or sesame oil once daily for 7 days. The blood pressure was measured fromthe rat tail by using BP Record. The heart rate was monitored and recorded at the same time byusing the same instrument. Blood samples were then collected by heart puncture under etheranesthesia. The hematocrit was determined by a microhematocrit centrifuge. Orchiectomy resultedin a significant decrease in hematocrit, systolic blood pressure and heart rate. The weight ofseminal vesicles and plasma testosterone were also decreased significantly (p<0.01). Replacementof TP in Orch rats restored hematocrit and heart rate to intact levels. The mechanism of testosterone to increase hematocrit was discussed in the present study. The possible reasons for systolicpressure changes after orchiectomy and TP replacement were also discussed. (JPTA ROC1996;21(1):41-45) |
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