頁籤選單縮合
題名 | Pharmacokinetics of Different Formulations of 2-Phenyl-4-quinolone in Rabbit= |
---|---|
作者 | 黃太鴻; 鄭信宏; 蔡尚元; 李珮端; 郭盛助; Huang, Tai-hung; Cheng, Hshin-horng; Tsai, Shang-yuang; Chao Lee, Pei-dawn; Kuo, Sheng-chu; |
期刊 | 中華藥學雜誌 |
出版日期 | 20010600 |
卷期 | 53:3 2001.06[民90.06] |
頁次 | 頁129-136 |
分類號 | 418.4 |
語文 | eng |
關鍵詞 | 2-Phenyl-4-quinolone; YT-1; Pharmacokinetics; Citric acid; Malic acid; |
英文摘要 | The pharmacokinetics of various formulations of 2-phenyl-4-quinolone (YT-1) were evaluated in rabbits after intravenous or oral administration. A two-compartment model best described the serum YT-1 concentration-time profile after intravenous administration whereas a noncompartment model was appropriate for oral administration of the various formulations. No significant difference was found between the pharmacokinetic parameters after intravenous and oral administrations of a YT-1/citric acid formulation. Conjugates of YT-1 accounted for 86 %, 83 % and 64 % of the circulating molecules in plasma for YT-1/malic acid, YT-1 and YT-1/citric acid formulations, respectively. Comparison of the pharmacokinetics indicated significant differences of Cmax and AUC among the various dosage forms. The mean absorption of YT-1/citric acid, YT-1 and YT-1/malic acid formulation were 86 %, 41 % and 46 % respectively, indicating that the YT-1/citric acid formulation was the best formulation prepared in this study. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。