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題名 | Hemodynamic Responses of Thiopental and Propofol in Different-Aged Patients during Endotracheal Intubation=Thiopental與Propofol於不同年齡的病人插管時的血流動力學 |
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作者 | 楊靖宇; 徐至清; 林俊明; 黃世仁; 鍾涵濡; 石明煌; Yang, Ching-yue; Hsu, Jee-ching; Lin, Chun-ming; Huang, Shih-jen; Chung, Ham-see; Shyr, Ming-hwang; |
期刊 | 長庚醫學 |
出版日期 | 20010600 |
卷期 | 24:6 2001.06[民90.06] |
頁次 | 頁376-382 |
分類號 | 416.5 |
語文 | eng |
關鍵詞 | 血壓; 心路; 插管; Propofol; Thiopental; Mean arterial pressure; Heart rate; Intubation; |
英文摘要 | Background: Thiopental and propofol are 2 popularly used anesthetic induction agents that have different pharmacological and pharmacokinetic actions. It is not clear how the hemodynamic responses differ in different-aged patients using these 2 drugs for anesthetic induction. The aim of this study was to investigate the hemodynamic responses to propofol and thiopental of different-aged patients during endotracheal intubation. Methods: Sixty patients, 20 to 83 years old, were included in this study. Patients were randomly divided into 6 groups according to age and different inductive anesthetics. Non-invasive blood pressure (NIBP) monitoring was performed every minute before anesthesia, during anesthetic induction with 5 mg!Dkg-1 thiopental or 2 mg!Dkg-1 propofol intravenously, and after intubation. Results: Propofol induction produced a smaller mean arterial pressure increase immediately after intubation than did thiopental induction in adult and elderly groups (101.0!O18.5 and 104.0!O21.1 mmHg in the propofol groups vs. 138.3!O17.1 and 138.9!O16.1 mmHg in the thiopental groups at 1 minute after intubation, p<0.001 and p=0.001, respectively). Differences in heart rate between propofol and thiopental groups were found in young and adult groups (85.1!O9.2 and 81.7!O10.9 in the propofol groups vs. 94.5!O9.9 and 95.0!O14.0 beats per minute in the thiopental groups at 1 minute after intubation, p=0.041 and p=0.029, respectively). Conclusion: Propofol induction produced more stable hemodynamics after intubation in adult and elderly patients than did thiopental induction. Therefore, it is safer to use propofol for induction and intubation in adult and elderly patients. (Chang Gung Med J 2001;24:376-82) |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。