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題名 | The Assay of Bone Reaction after Implantation of Calcium Sulfate and A Composite of Calcium Sulfate and Calcium Phosphate=骨組織對硫酸鈣加磷酸鈣之吸收性和骨再生性比較分析研究 |
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作者 | 王焯林; 靳應台; 曾慶誠; 林智一; 林世偉; 張冠諒; Wang, Jwo-lin; Zin, Ying-tai; Tzeng, Ching-cherng; Lin, Chin-i; Lin, Shi-wei; Chang, Guan-liang; |
期刊 | Journal of Medical and Biological Engineering |
出版日期 | 20031200 |
卷期 | 23:4 2003.12[民92.12] |
頁次 | 頁205-212 |
分類號 | 398.1 |
語文 | eng |
關鍵詞 | 硫酸鈣; 磷酸鈣; 骨移植; Calcium sulfate; Calcium phosphate; Bone graft; |
中文摘要 | 骨科手術中經常因骨折癒合不良、骨瘤、嚴重外傷或骨髓炎而需施行骨移植術,但臨床上往往難以取得足夠之海綿骨來配合手術,或因感染不適宜立即接受海棉骨移植,因而引發研究人員設法尋求替代物來協助醫師完成手術。這篇就是要以硫酸鈣及硫酸鈣和磷酸鈣之混合物植入大白兔脛骨骺內,觀察其吸收、骨化及骨組織之反應,做為將來進人體實驗之基礎。我們將6隻紐西蘭大白兔分成三組,每組兩隻。分別於左右兩側脛骨近端內側海綿骨處植入硫酸鈣及硫酸鈣和磷酸鈣之混合物所製成的圓柱體,並分別飼養6週、12週及24週後犧牲兔隻,取出標本在顯微鏡下觀察。實驗結果發現硫酸鈣對骨組織並沒有明顯的炎性反應,其一旦接觸骨膜或骨內膜等含有原生骨細胞時,則有明顯刺激骨增生作用,而骨髓內之硫酸鈣,因吸收過快,最終被結締組織或脂肪所取代,因此硫酸鈣並不適合單獨作為骨移植替代物。磷酸鈣雖不具有骨增生作用,但有骨傳導支持作用,也不會引起明顯的炎性反應,因此和硫酸鈣混合後,利用硫酸鈣快速被吸收當作製造骨基質原料及產生空洞效果的特性,有利於新骨長入,所以這兩種材料結合後,彼此不同之特性相輔相成,因此硫酸鈣和磷酸鈣和混合物不失為一理想的骨移植替代物。 |
英文摘要 | The in vivo implantation of calcium sulfate and a composite of calcium sulfate and calcium phosphate of the proximal epiphysis of tibia of the rabbit was investigated to evaluate biocompatibility, bioabsorbability and biodegradability. The materials were in situ for 6, 12 and 24 weeks in 3 different groups of rabbits in all 6 cases. Light microscopy reveals calcium sulfate in bone marrow is completely resorbed and replaced by connective tissue and fatty tissue. Significant osteogenesis is noted once calcium sulfate contacts with periosteum and endosteum. We do not recommend use of calcium sulfate as filler of bone defect because new bone formation is not ideal due to fast absorption of implant. A composite of calcium sulfate and calcium phosphate is slowly resorbed. The absorbed calcium sulfate will be used as materials of bone matrix. It will cause a porous effect in composite. The newly formed bone integrates into the implant along with the pore and contacts directly with crystals of calcium phosphate. Osteoblasts are in direct contact with implanted granules of calcium phosphate. There is no evidence of acute or chronic inflammation. Therefore a composite of calcium sulfate and calcium phosphate is considered a good choice of bone defect filler. |
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