頁籤選單縮合
題名 | Comparison of the Immunogenicity of Wasp Venom Peptides with or Without Carbohydrate Moieties= |
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作者 | Ho,Chewn-lang; Lin,Yah-luen; Chen,Wan-chen; Rocchi,Raniero; Piek,Tom; |
期刊 | 中央研究院生物化學研究所論文集 |
出版日期 | 19980000 |
卷期 | 24 1998[民87.] |
頁次 | 頁123-127 |
分類號 | 361.19 |
語文 | eng |
關鍵詞 | Comparison of the immunogenicity of wasp venom peptides; Carbohydrate moieties; |
英文摘要 | Three synthetic vespulakinin analogues either with or without carbohydrate moieties and mastoparan B isolated from Vespa basalis venom were investigated for their immunogenic activity and solution conformation. Mice immunized wilh these wasp venom peptides. with the exception of (Galα)Thr ��. (Galα)Thr ��- vespulakinin 1. showed positive antibody responses. However, the response elicited by mastoparan B was much higher than those induced by vespulakinin analogues. The class of antibody induced by these peptides was identified as an lgG �� isotype with �R -light chain, suggesting stimulation of a T-celldependent immune response by these peptides. According to the circular dichroism spectra of these peptides. the structures of the vespulakinin analogues in solution were largely unordered, while mastoparan B exhibited a conformation rich in α -helices. The presence of carbohydrate moieties and the rather random structure in vespulakinins may interfere with T-cell recognition of the peptides. leading to lower immune responses. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。