頁籤選單縮合
題名 | Anesthetics Attenuate Ischemia--Reperfusion Induced Renal Injury: Effects and Mechanisms= |
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作者 | Khajuria, Ankur; Tay, Charison; Shi, Jiaqi; Zhao, Hailin; Ma, Daqing; |
期刊 | Acta Anaesthesiologica Taiwanica |
出版日期 | 20141200 |
卷期 | 52:4 2014.12[民103.12] |
頁次 | 頁176-184 |
分類號 | 418.215 |
語文 | eng |
關鍵詞 | Anesthetics; Ischemia-reperfusion injury; Mechanism; Renal injury; |
英文摘要 | Acute kidney injury (AKI) secondary to ischemiaereperfusion injury (IRI) is a major cause of patient morbidity and mortality in the perioperative period. It can lead to new onset of chronic kidney disease and accelerate its progression. Patients with risk factors undergoing cardiac, vascular, and liver transplantation surgeries, which may inevitably involve IRI, are more susceptible to AKI. Anesthetic agents have been postulated to possess renoprotective properties. Thus, exploring the utilization of selective perioperative anesthetic agents with renoprotective properties may be a promising avenue to reduce the risk of AKI. This review discusses the effects and mechanisms of dexmedetomidine, inhalational and intravenous anesthetics, and xenon-mediated renoprotection. Although the renoprotective effects of these agents obtained in the laboratory are promising, much work especially via clinical trials is required to determine the translational value from the bench to the bedside. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。