查詢結果分析
相關文獻
- Caffeine Clearance Test: A Quantitative Liver Function Assessment in Patients with Liver Cirrhosis
- Pulmonary Function Changes in Cirrhotic Patients
- Recurrent Spontaneous Bacterial Empyema in Cirrhosis: A Case Report
- 肝硬化患者之細菌性感染--157位病例研究
- Isolated Fundic Varices in Liver Cirrhosis
- 肝硬化的病理治則機轉
- Can Advanced Hemostatic Parameters Detect Disseminated Intravascular Coagulation More Accurately in Patients with Cirrhosis of the Liver?
- Can the Screening Clotting Tests Predict the Complicated Hemostatic Changes in Patients with Cirrhosis of Liver?
- 壞死後肝硬化病患的營養評估
- 肝硬化腹水的治療
頁籤選單縮合
題名 | Caffeine Clearance Test: A Quantitative Liver Function Assessment in Patients with Liver Cirrhosis=以血清咖啡因廓清率定量評估肝硬化病人之肝功能 |
---|---|
作者 | 徐積寬; 王苑貞; 李壽東; 盧瑞華; 羅光瑞; Shyu, Ji-kuan; Wang, Yuan-jen; Lee, Shou-dong; Lu, Rei-hwa; Lo, Kwang-juei; |
期刊 | 中華醫學雜誌 |
出版日期 | 19960500 |
卷期 | 57:5 1996.05[民85.05] |
頁次 | 頁329-334 |
分類號 | 415.53 |
語文 | eng |
關鍵詞 | 咖啡因廓清率; 肝硬化; 定量肝功能; Caffeine clearance; Cirrhosis; Quantitative liver function; |
中文摘要 | 背景 肝功能的評估對於肝硬化患者而言有其臨床上的重要性。本研 究的目的在於證實咖啡因廓清率在定量檢測肝功能上扮演的角色。 方法 本研究選擇了28位肝硬化病人及28位健康志願者;在經過12小時禁食 後,受試者於8:00抽取空腹靜脈血4c.c.後,服下150毫克咖啡因;此後分別在 8:30、9:00、11:00、14:00及17:00等五個時刻抽血檢測咖啡因濃度,我們選擇清 除期(elimination phase)的最後兩點濃度,亦即14:00和17:00的血清濃度來決定咖 啡因廓清率。 結果 咖啡因廓清率在對照組顯著地高於疾病組(1.2+/-1.06對0.78+/-0.77 ml/min/kg,p<0.0001),而半衰期則較短(2.69+/-0.75對3.74+/-1.05 hours,p<0.0001)。 此外,抽煙者具有較高的廓清率及較短半衰期(對照組中,抽煙者與非抽煙者 在廓清率及半衰期的比較上,分別為2.30+/-0.98對1.30+/-0.90 ml/min/kg和 2.41+/-0.63對2.89+/-0.78 hours,p<0.05;而疾病組中則分別為1.13+/-0.96對 0.51+/-0.47 ml/min/kg和3.31+/-l.06對4.06+/-0.93 hours,p<0.05)。本研究也對所 有病患予以定期追蹤,平均6個月的追蹤期間,廓清率大於及小於0.5 ml/min/kg 的兩組在死亡率上有顯著差異(67%及46.1%,p<0.05)。此外,疾病組中,咖啡 因廓清率與Child-Pugh's分數間存有高度的負相關性(gamma=-0.851,p<0.0001)。 結論 我們認為咖啡因廓清率不但是檢測肝功能的理想方法,同時也可視為短 期預後的良好指標。 |
英文摘要 | Background. Quantitative assessment of liver function is an important work-up for patients with liver cirrhosis. The aim of the present study was to clarify the role of caffeine clearance test in the quantitative measurement of metabolizing capacity of the liver. Methods. Twenty-eight patients with liver cirrhosis and 28 normal healthy volunteers were enrolled in this study. After an overnight fast, the first blood sample was collected at 8 a.m., immediately followed by an oral administration of 150 mg caffeine. Subsequent samples of venous blood were obtained at 8:30 a.m., 9 a.m., 11 a.m., 2 p.m. and 5 p.m. The caffeine clearance was determined using two caffeine concentrations from blood samples taken at 2 p.m. and 5 p.m., which were then measured by an enzyme multiple immunoassay technique. Results. The serum caffeine clearance was significantly higher in the control group than in the patient group (1.72 +/- 1.06 vs. 0.78 +/- 0.77 ml/min/kg, p<0.0001). Elimination half-life was significantly prolonged in the patient group (3.74 +/- 1.05 vs. 2.69 +/- 0.75 hours, p<0.0001). The influence of cigarette smoking was also evident: higher clearance and shorter half-life of caffeine were noted in the smoking subjects. In the non-smokers, caffeine clearance was 1.30 +/- 0.90 and 0.51 +/- 0.47 ml/min/kg and half-life of caffeine was 2.89 +/- 0.78 and 4.06 +/- 0.93 hours, respectively (control vs. patient, p<0.05). In the smokers, caffeine clearance was 2.30 +/- 0.98 and 1.13 +/- 0.96 ml/min/kg and half-life of caffeine was 2.41 +/- 0.63 vs. 3.31 +/- 1.06 hours, respectively (control vs. patient, p<0.05). During the mean six-month period of follow-up, the mortality rate was significantly higher in those patients with caffeine clearance less than 0.5 ml/min/kg than in those with clearance more than 0.5 ml/min/kg (46.1% vs. 6.7%, p<0.05). A significantly negative correlation between the serum caffeine clearance and the Child-Pugh's score was also demonstrated (r = -0.851, p<0.0001). Conclusions. Serum caffeine clearance determined at two points of blood concentration is a useful method to evaluate the severity of liver disease and predict short-term survival of cirrhotic patients. It offers another choice for the quantitative measurement of liver functional reservoir. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。