查詢結果分析
相關文獻
- Comparison of Safety and Efficacy of Erysipelas Inactivated and Attenuated Vaccines in Mice and Pigs
- Comparison of Safety and Efficacy of Erysipelas Inactivated and Attenuated Vaccines in Mice and Pigs
- 豬丹毒多價不活化菌苗之田間應用試驗--添加抗菌物質飼料對豬丹毒菌苗免疫效果影響評估試驗
- LPC細胞培養豬瘟及豬丹毒混合雙價活毒疫苗免疫效力探討
- 豬博德氏菌、巴氏桿菌、放線桿菌、丹毒絲狀菌及假性狂犬病不活化五合一混合疫苗之研製與田間應用試驗
- 淡水養殖魚類產氣單胞菌不活化菌苗之研發與應用之評估
- Safety and Potency of a Five-in-one Inactivated Vaccine Against Erysipelothrix rhusiopathiae Challenge in Mice
- 豬細菌性疾病--豬丹毒(Erysipelas)
- 檢討豬丹毒抗體價與接種適期
- 國產與進口豬萎縮性鼻炎菌苗之效力評估
頁籤選單縮合
題名 | Comparison of Safety and Efficacy of Erysipelas Inactivated and Attenuated Vaccines in Mice and Pigs=豬丹毒不活化菌苗與弱毒活菌苗之安全與免疫效力 |
---|---|
作者 | 陳清; 呂清泉; 林旭志; 郭乃維; 詹益波; Chen, Ching; Lu, Ching-chuan; Lin, Shiuh-chih; Kuo, Nae-wei; Chan, I-po; |
期刊 | 臺灣省家畜衛生試驗所研究報告 |
出版日期 | 19981200 |
卷期 | 34 1998.12[民87.12] |
頁次 | 頁85-93 |
分類號 | 437.245 |
語文 | eng |
關鍵詞 | 豬丹毒; 不活化菌苗; 弱毒活菌苗; 免疫效力; Erysipelas; Inactivated bacterin; Attenuated vaccine; Immunity potency; |
中文摘要 | 試製之豬丹毒不活化菌苗與弱毒活菌苗,以小白鼠及豬隻作安全及免疫效力試 驗之結果,得知兩者對供試動物均無不良之接種反應。小白鼠即使注射10倍豬免疫劑 量之弱毒活菌苗亦無任何不良反應,而接種1.4×10�崟FU/Mouse/SC即可耐過100MLD 之攻擊。另一方面不活化菌苗,其安全性雖甚佳,但免疫效力要達耐過100 MLD之攻 擊,則需3×10�蹝FU/Mouse/SC以上。4頭豬隻免疫接種弱毒活菌苗2週後血清,對 豬丹毒強毒株(la)發育凝集抗體價(G A tiyer)達1:32,攻擊後2週其抗體價亦無 明顯改變。但6頭豬隻接種不活化菌苗2週後其血清中發育凝集抗體價均為1:8,攻 擊後2週則達1:128-1:512不等。此等高抗體價顯然是攻擊耐過之免疫反應。由試驗 結果顯示,弱毒活菌苗效果優於不活化菌苗。 |
英文摘要 | Mice and pigs were used to test the safety and efficacy of mono-and poly-valent inactivated vaccines and mono-valent attenuated vaccine of erysipelas. The results showed no side reactions on either experimental animals, even when 10 times doses for pigs were used in mice. When the mice were immunized, subcutaneously, with 14 × 10 �� CFU of attenuated vaccine they resisted to the challenge of 100 MLD of a virulent Erysipelothrix rhusiopathiae (Er). Although the inactivated vaccine is very safe, a vaccination dose of 3 × 10 �� CFU was required for the protection from the 100 MLD challenge. On the other hand, the growth agglutination (GA) titers of four pigs were 1:32 when the sera were collected at two weeks after vaccination using attenuated vaccine. In addition, no distinct changes in the GA titers were found at two weeks after challenge (4 weeks after vaccination). However, the GA titer were 1:8 for other 6 pigs when the sera were tested at 2 weeks after vaccination with inactivated vaccine. The titers increased to 1:128 to 1:512 when the sera were tested at two weeks after challenge. These increased titer were apparently due to the exposure of pigs to challenge with Er. The results indicated that the efficacy of the attenuated vaccine is better than that of the inactivated bacterin. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。